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  • Exfoliation SIG Corner

    SIG Corner Editor: Hana Abouzeid Chair: Gabor Hollo Co-chair: Anastasios G. Konstas The goal of this SIG is to increase ophthalmologists’ knowledge...

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    Exfoliation SIG Corner

    Exfoliation SIG Corner

    SIG Corner Editor: Hana Abouzeid Chair: Gabor Hollo Co-chair: Anastasios G. Konstas The goal of...

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  • IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

    Purpose: Expansion of the suprachoroidal space (SCS) by a hydrogel injection has been shown to reduce intraocular pressure (IOP) in rabbits as a...

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    IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

    IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

    Purpose: Expansion of the suprachoroidal space (SCS) by a hydrogel injection has been shown to...

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  • Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study

    Purpose: To investigate whether intraocular pressure (IOP) fluctuation is associated independently with the rate of visual field (VF) progression...

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    Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study

    Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study

    Purpose: To investigate whether intraocular pressure (IOP) fluctuation is associated...

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  • Using anterior segment OCT to risk-stratify primary angle closure suspects

    Gonioscopy is the clinical standard for detecting patients at risk for primary angle closure glaucoma (PACG). However, anterior chamber angle...

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    Using anterior segment OCT to risk-stratify primary angle closure suspects

    Using anterior segment OCT to risk-stratify primary angle closure suspects

    Gonioscopy is the clinical standard for detecting patients at risk for primary angle closure...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

Clinical paper of the month

Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

Author(s): Nathan Ingold (1,2), Adrian I Campos (1,3), Xikun Han (1,3), Jue-Sheng Ong (1), Puya Gharahkhani (1), David A Mackey (4), Miguel E...

April 30, 2022

Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

Experimental Paper of the Month

Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

Author(s): Nathan Ingold (1,2), Adrian I Campos (1,3), Xikun Han (1,3), Jue-Sheng Ong (1), Puya Gharahkhani (1), David A Mackey (4), Miguel E...

April 30, 2022

Be aware of glaucoma therapy-related ocular surface disease when planning filtration surgery!

Tip of the month

Be aware of glaucoma therapy-related ocular surface disease when planning filtration surgery!

Glaucoma eye drops, especially when containing preservatives, are responsible for clinical or subclinical ocular surface alterations (1). Amongst...

March 31, 2022

Policy-Driven, Multimodal Deep Learning for Predicting Visual Fields from the Optic Disc and Optical Coherence Tomography Imaging

Clinical paper of the month

Policy-Driven, Multimodal Deep Learning for Predicting Visual Fields from the Optic Disc and Optical Coherence Tomography Imaging

Author(s): Yuka Kihara (1), Giovanni Montesano (2), Andrew Chen (1), Nishani Amerasinghe (3), Chrysostomos Dimitriou (4), Aby Jacob (3), Almira...

March 31, 2022

Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma

Experimental Paper of the Month

Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma

Author(s): Luis Alarcon-Martinez (1,2), Yukihiro Shiga (3,2), Deborah Villafranca-Baughman )3,2), Nicolas Belforte (3,2), Heberto Quintero (3,2),...

March 31, 2022

Intraocular Pressure and Its Relation to Ocular Geometry: Results From the Gutenberg Health Study

NGP Paper

Intraocular Pressure and Its Relation to Ocular Geometry: Results From the Gutenberg Health Study

Author(s): Esther M Hoffmann (1), Fidan Aghayeva (1), Felix M Wagner (1), Achim Fiess (1), Markus Nagler (2), Thomas Münzel (3,4), Philipp S Wild...

March 30, 2022

When prescribing Latanoprost, don’t forget about potential cardiovascular side effects

Tip of the month

When prescribing Latanoprost, don’t forget about potential cardiovascular side effects

Prostaglandin analogues are advised as first line treatment for chronic open angle glaucoma by the European Glaucoma Society Guidelines for their...

February 28, 2022

The Weiss ring, a major confounding factor for measurements of peripapillary retinal nerve fiber layer thickness

Clinical paper of the month

The Weiss ring, a major confounding factor for measurements of peripapillary retinal nerve fiber layer thickness

Author(s): Min-Woo Lee (1), Min-Su Kim (2), Hwa-Young Yu (1), Kee-Sup Park (1), Young-Hoon Lee (1), Jung-Yeul Kim (3) 1 Department of...

February 28, 2022

GWAS identifies two common loci associated with pigment dispersion syndrome/pigmentary glaucoma and implicate myopia in its development

Experimental Paper of the Month

GWAS identifies two common loci associated with pigment dispersion syndrome/pigmentary glaucoma and implicate myopia in its development

Author(s): Mark J Simcoe (1), Ameet Shah (2), Baojian Fan (3), Hélène Choquet (4), Nicole Weisschuh (5), Naushin H Waseem (6), Chen Jiang (4),...

February 28, 2022

Neuroprotection SIG

SIG Corner

Neuroprotection SIG

SIG Corner Editor: Hana Abouzeid Chair: Maria Francesca Cordeiro Co-chair: Miriam Kolko SIG neuroprotection keeps an eye on new initiatives within...

February 21, 2022

Unilateral ocular hypertension: have a look at the corneal endothelium

Tip of the month

Unilateral ocular hypertension: have a look at the corneal endothelium

Unilateral ocular hypertension or glaucoma is often associated with secondary causes that should be explored to ascertain the visual prognosis and...

January 31, 2022

Diagnostic assessment of glaucoma and non-glaucomatous optic neuropathies via optical texture analysis of the retinal nerve fibre layer

Clinical paper of the month

Diagnostic assessment of glaucoma and non-glaucomatous optic neuropathies via optical texture analysis of the retinal nerve fibre layer

Author(s): Christopher Kai Shun Leung (1,2,3,4), Alexander Ka Ngai Lam (5), Robert Neal Weinreb (6), David F Garway-Heath (7), Marco Yu (8), Philip...

January 31, 2022

Phase 1b Randomized Controlled Study of Short Course Topical Recombinant Human Nerve Growth Factor (rhNGF) for Neuroenhancement in Glaucoma: Safety, Tolerability, and Efficacy Measure Outcomes

Experimental Paper of the Month

Phase 1b Randomized Controlled Study of Short Course Topical Recombinant Human Nerve Growth Factor (rhNGF) for Neuroenhancement in Glaucoma: Safety, Tolerability, and Efficacy Measure Outcomes

Author(s): Gala Beykin (1), Laurel Stell (1), Muhammad Sohail Halim (1), Mariana Nuñez (1), Lilia Popova (1), Bac T Nguyen (1), Sylvia L Groth (1),...

January 31, 2022

Mind the depth – forward displacement of the lens-iris diaphragm and myopic shift after ophthalmic surgery is suggestive of aqueous misdirection

Tip of the month

Mind the depth – forward displacement of the lens-iris diaphragm and myopic shift after ophthalmic surgery is suggestive of aqueous misdirection

Aqueous misdirection is a serious condition with potentially higher prevalence than expected. Predominantly observed after ocular surgery,...

December 31, 2021

Attitudes towards polygenic risk testing in individuals with glaucoma

Clinical paper of the month

Attitudes towards polygenic risk testing in individuals with glaucoma

Author(s): Georgina L Hollitt (1), Owen M Siggs (2), Bronwyn Ridge (2), Miriam C Keane (2), David A Mackey (3), Stuart MacGregor (4), Alex W Hewitt...

December 31, 2021

Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies

Experimental Paper of the Month

Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies

Author(s): Benjamin R Thomson (1,2), Pan Liu (1,2), Tuncer Onay (1), Jing Du (1,2), Stuart W Tompson (3), Sol Misener (1,2), Raj R Purohit (1,2),...

December 31, 2021

Virtual Reality-Based and Conventional Visual Field Examination Comparison in Healthy and Glaucoma Patients

NGP Paper

Virtual Reality-Based and Conventional Visual Field Examination Comparison in Healthy and Glaucoma Patients

Author(s): Jan Stapelfeldt (1), Serife Seda Kucur (1), Nina Huber (1), René Höhn (2), Raphael Sznitman (1) 1 ARTORG Center for Biomedical...

December 30, 2021

Exfoliation (pseudoexfoliation) syndrome (with or without glaucoma) is associated with clinically significant non-vascular systemic diseases

Tip of the month

Exfoliation (pseudoexfoliation) syndrome (with or without glaucoma) is associated with clinically significant non-vascular systemic diseases

The association of systemic vascular dysfunction and vascular diseases with exfoliation syndrome have been extensively studied in the last decades....

December 01, 2021

Association Between Visual Field Damage and Gait Dysfunction in Patients With Glaucoma

Clinical paper of the month

Association Between Visual Field Damage and Gait Dysfunction in Patients With Glaucoma

Author(s): Jian-Yu E (1,2), Aleksandra Mihailovic (1), Catalina Garzon (1), Jennifer A Schrack (2,3), Tianjing Li (4), Sheila K West (1), Laura N...

November 30, 2021

GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans

Experimental Paper of the Month

GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans

Author(s): K Saidas Nair (# 1), Chitrangda Srivastava (# 2), Robert V Brown (# 2), Swanand Koli (3), Hélène Choquet (4), Hong Soon Kang (2),...

November 30, 2021

Unplanned Return to the Operating Room After Trabeculectomy

Clinical paper of the month

Unplanned Return to the Operating Room After Trabeculectomy

Author(s): Nur Cardakli (1), David S Friedman (2), Michael V Boland (3) 1 Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins...

November 30, 2021

Exfoliation SIG

SIG Corner

Exfoliation SIG

The goal of this SIG is to increase ophthalmologists’ knowledge on XFS and XFG, and to support the optimal clinical care in XFG in Europe. 1....

November 01, 2021

Consider trabeculectomy as initial treatment for newly diagnosed advanced primary open angle glaucoma (POAG)

Tip of the month

Consider trabeculectomy as initial treatment for newly diagnosed advanced primary open angle glaucoma (POAG)

IOP control is of uttermost importance in advanced glaucoma to prevent blindness. The EGS guidelines recommend IOP in the low teens, e.g. 10-12mmHg...

October 31, 2021

In vivo imaging of the Schlemm's Canal and the response to Selective laser trabeculoplasty

Clinical paper of the month

In vivo imaging of the Schlemm's Canal and the response to Selective laser trabeculoplasty

Author(s): Toshit Varshney (1), Kishan Azmira (1), Shikha Gupta (1), Karthikeyan Mahalingam (1), Abhishek Singh (1), Dewang Angmo (1), Viney Gupta...

October 31, 2021

Preservation of vision after CaMKII-mediated protection of retinal ganglion cells

Experimental Paper of the Month

Preservation of vision after CaMKII-mediated protection of retinal ganglion cells

Author(s): 1 Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 2 Department of Neuroscience, Yale...

October 31, 2021