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  • Exfoliation SIG Corner

    SIG Corner Editor: Hana Abouzeid Chair: Gabor Hollo Co-chair: Anastasios G. Konstas The goal of this SIG is to increase ophthalmologists’ knowledge...

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    Exfoliation SIG Corner

    Exfoliation SIG Corner

    SIG Corner Editor: Hana Abouzeid Chair: Gabor Hollo Co-chair: Anastasios G. Konstas The goal of...

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  • IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

    Purpose: Expansion of the suprachoroidal space (SCS) by a hydrogel injection has been shown to reduce intraocular pressure (IOP) in rabbits as a...

    Learn more...
    IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

    IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

    Purpose: Expansion of the suprachoroidal space (SCS) by a hydrogel injection has been shown to...

    Learn more...
  • Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study

    Purpose: To investigate whether intraocular pressure (IOP) fluctuation is associated independently with the rate of visual field (VF) progression...

    Learn more...
    Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study

    Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study

    Purpose: To investigate whether intraocular pressure (IOP) fluctuation is associated...

    Learn more...
  • Using anterior segment OCT to risk-stratify primary angle closure suspects

    Gonioscopy is the clinical standard for detecting patients at risk for primary angle closure glaucoma (PACG). However, anterior chamber angle...

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    Using anterior segment OCT to risk-stratify primary angle closure suspects

    Using anterior segment OCT to risk-stratify primary angle closure suspects

    Gonioscopy is the clinical standard for detecting patients at risk for primary angle closure...

    Learn more...
  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

    Learn more...
  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Exfoliation SIG Corner

SIG Corner Exfoliation SIG

Exfoliation SIG Corner

SIG Corner Editor: Hana Abouzeid Chair: Gabor Hollo Co-chair: Anastasios G. Konstas The goal of this SIG is to increase ophthalmologists’ knowledge...

October 15, 2024

IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

Experimental Paper of the Month

IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

Purpose: Expansion of the suprachoroidal space (SCS) by a hydrogel injection has been shown to reduce intraocular pressure (IOP) in rabbits as a...

October 15, 2024

Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study

Clinical paper of the month

Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study

Purpose: To investigate whether intraocular pressure (IOP) fluctuation is associated independently with the rate of visual field (VF) progression...

October 15, 2024

Using anterior segment OCT to risk-stratify primary angle closure suspects

Tip of the month

Using anterior segment OCT to risk-stratify primary angle closure suspects

Gonioscopy is the clinical standard for detecting patients at risk for primary angle closure glaucoma (PACG). However, anterior chamber angle...

October 13, 2024

Balancing Glaucoma Care: Tackling Overdiagnosis and Overtreatment to Preserve Patient Quality of Life

Tip of the month

Balancing Glaucoma Care: Tackling Overdiagnosis and Overtreatment to Preserve Patient Quality of Life

The Science behind the Tip In contrast to underdiagnosis, which has been described in population-based studies as affecting 50% or more of glaucoma...

September 12, 2024

Peripapillary Retinoschisis in Glaucoma: A Systematic Review

NGP Paper

Peripapillary Retinoschisis in Glaucoma: A Systematic Review

PURPOSE: The frequent use of optical coherence tomography increased the detection of peripapillary retinoschisis, which poses challenges in the...

September 12, 2024

Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study

Clinical paper of the month

Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study

Purpose: To determine whether primary trabeculectomy or medical treatment produces better outcomes in terms of quality of life (QoL), clinical...

September 12, 2024

Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension

Experimental Paper of the Month

Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension

Purpose: The Rho-associated protein kinase and myosin light chain kinase (ROCK/MYLK) pathway undeniably plays a pivotal role in the pathophysiology...

September 12, 2024

Surgery SIG corner

SIG Corner

Surgery SIG corner

SIG Corner Editor: Hana Abou Zeid Chair: Julian Garcia Feijoo Co-chair: Keith Barton Preserflo MicroShunt: Minimizing Corneal Endothelial Cell...

July 21, 2024

Consider a concomitant neurological disease in a glaucoma patient when there is only partial topographic agreement between structure and function.

Tip of the month

Consider a concomitant neurological disease in a glaucoma patient when there is only partial topographic agreement between structure and function.

The Science behind the Tip One of the key elements in the diagnosis and monitoring of glaucoma is the assessment of the topographic agreement...

July 14, 2024

Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

Experimental Paper of the Month

Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

Purpose: Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with glucocorticoids (GCs), resulting in irreversible...

July 11, 2024

Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

Clinical paper of the month

Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma and all licensed treatments lower IOP. However, many patients...

July 11, 2024

Tip: Not every peripapillary hemorrhage is a sign for glaucoma

Tip of the month

Tip: Not every peripapillary hemorrhage is a sign for glaucoma

The Science behind the Tip Most of the time, disc hemorrhages in patients with glaucoma are related to the disease itself. Although the strong...

June 16, 2024

The Factors Affecting the Stability of IOP Homeostasis

Experimental Paper of the Month

The Factors Affecting the Stability of IOP Homeostasis

Purpose: Shear-induced nitric oxide (NO) production by Schlemm's canal (SC) endothelial cells provides a fast, IOP-sensitive feedback signal that...

June 16, 2024

Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study

Clinical paper of the month

Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study

Purpose: To evaluate the performance of an intensive, clustered testing approach in identifying eyes with rapid glaucoma progression over 6 months...

June 16, 2024

Treatment Outcomes Comparing the Paul and Baerveldt Glaucoma Implants After One Year of Follow-Up

NGP Paper

Treatment Outcomes Comparing the Paul and Baerveldt Glaucoma Implants After One Year of Follow-Up

PURPOSE: To compare efficacy and safety profiles of the Paul Glaucoma Implant (PGI) and Baerveldt Glaucoma Implant (BGI) in the treatment of...

June 16, 2024

TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

Experimental Paper of the Month

TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage

Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2) cause a multisystem disorder that includes ocular...

May 15, 2024

Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

Clinical paper of the month

Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma

Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by spectral-domain optical coherence tomography (OCT)...

May 15, 2024

Disease progression, irrespective of intraocular pressure, should guide escalation of treatment in glaucoma

Tip of the month

Disease progression, irrespective of intraocular pressure, should guide escalation of treatment in glaucoma

The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to slow down disease progression. Intraocular...

May 15, 2024

Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

Experimental Paper of the Month

Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

Previous studies of neuronal survival have primarily focused on identifying intrinsic mechanisms controlling the process. This study explored how...

April 15, 2024

Comparison of intraocular pressure profiles during the water drinking test and the modified diurnal tension curve

Clinical paper of the month

Comparison of intraocular pressure profiles during the water drinking test and the modified diurnal tension curve

Objectives: To compare intraocular pressure (IOP) during the water drinking test (WDT) and modified diurnal tension curve (mDTC) in open-angle...

April 15, 2024

Systemic β-blockers may have a heterogenous impact on glaucoma patients

Tip of the month

Systemic β-blockers may have a heterogenous impact on glaucoma patients

The Science behind the Tip Systemic β-blockers could reach the ciliary body epithelium and are associated with lower intraocular pressure. Thus,...

April 15, 2024

Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

NGP Paper

Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate their impact on success rates. DESIGN: Systematic...

March 14, 2024

A foundation model for generalizable disease detection from retinal images

Experimental Paper of the Month

A foundation model for generalizable disease detection from retinal images

Medical artificial intelligence (Al) offers great potential for recognizing signs of health conditions in retinal images and expediting the...

March 14, 2024

Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

Clinical paper of the month

Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation compares medical and surgical management...

March 14, 2024