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Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells
Previous studies of neuronal survival have primarily focused on identifying intrinsic mechanisms...
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Comparison of intraocular pressure profiles during the water drinking test and the modified diurnal tension curve
Objectives: To compare intraocular pressure (IOP) during the water drinking test (WDT) and...
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Systemic β-blockers may have a heterogenous impact on glaucoma patients
The Science behind the Tip Systemic β-blockers could reach the ciliary body epithelium and are...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer
Author(s): Ronen E Mukamel (1), Robert E Handsaker (2), Maxwell A Sherman (3), Alison R Barton (4), Margaux L A Hujoel (5), Steven A McCarroll (6),...
September 15, 2023
Long-term Impact of Immediate Versus Delayed Treatment of Early Glaucoma: Results From the Early Manifest Glaucoma Trial
PURPOSE: To compare long-term visual outcomes in the 2 arms of the Early Manifest Glaucoma Trial (EMGT) and determine if delayed treatment was...
September 15, 2023
OCT Imaging of glaucoma patients at 6-month intervals may enhance progression detection while reducing the healthcare burden of more frequent testing
The Science behind the Tip Thanks to its high reproducibility,1-3 OCT has become widely used for monitoring structural optic nerve changes in...
September 15, 2023
Intravitreal bevacizumab improves trabeculectomy survival at 12 months: the bevacizumab in trabeculectomy study-a randomised clinical trial
Author(s): John A Landers, Sean Mullany, Jamie E Craig 1 Ophthalmology, Flinders University of South Australia, Adelaide, South Australia,...
September 15, 2023
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Glaucoma control can be detrimentally affected by recurrent anti- VEGF treatment for macular degeneration or diabetic macular oedema
The Science behind the Tip Patients undergoing anti-VEGF (vascular endothelial growth factor) therapy for age-related macular degeneration or...
August 31, 2023
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...
July 30, 2023
Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...
July 30, 2023
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...
July 30, 2023
Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...
July 30, 2023
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Ligand-induced activation and G protein coupling of prostaglandin F2α receptor
Author(s): Canrong Wu (1), Youwei Xu (2), Qian He (2), Dianrong Li (3), Jia Duan (2), Changyao Li (4,5), Chongzhao You (2), Han Chen (6), Weiliang...
June 30, 2023
Fast Progressors in Glaucoma: Prevalence Based on Global and Central Visual Field Loss
Author(s): Aidan B Jackson (1), Keith R Martin (2), Michael A Coote (1), Felipe A Medeiros (3), Christopher A Girkin (4), Massimo A Fazio (4),...
June 30, 2023
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...
June 30, 2023
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When interpreting RNFL OCT scans, attention should be paid to the presence of peripapillary retinoschisis
Peripapillary retinoschisis (PPRS) occurs significantly more frequently in glaucoma patients (1%-6%) compared to healthy subjects (0.5%) (1). The...
June 30, 2023
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Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia
Author(s): Mahmoud T KhalafAllah (1,2), Preston A Fuchs (3), Fred Nugen (3), Mustapha El Hamdaoui (3), Alexander Levy (4), David T Redden (5),...
May 31, 2023
Validation of Rates of Mean Deviation Change as Clinically Relevant End Points for Glaucoma Progression
Author(s): Felipe A Medeiros (1), Alessandro A Jammal (2) 1 Vision, Imaging and Performance Laboratory, Duke Eye Center, Duke University, Durham,...
May 31, 2023
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OCT can be a helpful additional tool to differentiate glaucoma from other optic neuropathi
Differentiating between glaucomatous and non-glaucomatous optic neuropathies can be quite challenging. In addition to a thorough clinical history...
May 31, 2023
MIND diet lowers risk of open-angle glaucoma: the Rotterdam Study
Author(s): Joëlle E Vergroesen (1,2), Tosca O E de Crom (2), Cornelia M van Duijn (3), Trudy Voortman (2,4), Caroline C W Klaver (1,2,5,6), Wishal...
April 30, 2023
Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...
April 21, 2023
Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma
Author(s): Jae H Kang (1), Oana Zeleznik (1), Lisa Frueh (1), Jessica Lasky-Su (1), A Heather Eliassen (1,2), Clary Clish (3), Bernard A Rosner...
April 01, 2023
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Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant
Author(s): W Daniel Stamer (1), Kristin M Perkumas (1), Min H Kang (2), Mohammed Dibas (3), Michael R Robinson (3), Douglas J Rhee (2) 1 Department...
March 31, 2023
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Use corneal hysteresis to identify high-risk glaucoma patients
Identifying those patients at greater risk of disease progression is a key step in glaucoma management algorithms. Several variables have been...
March 31, 2023
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
Author(s): Thai Ling Wong (1), Juan Lyn Ang (2), Sundeep Deol (2), Fiona Buckmaster (1), Alice D. McTrusty (1) and Andrew J. Tatham (1,2) 1 Centre...
March 30, 2023
Evidence-Based Guidelines for the Number of Peripapillary OCT Scans Needed to Detect Glaucoma Worsening
Author(s): Chris Bradley (1), Kaihua Hou (2), Patrick Herbert (2), Mathias Unberath (2), Michael V Boland (3), Pradeep Ramulu (4), Jithin Yohannan...
March 01, 2023
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Intracameral Injection of AAV-DJ.COMP-ANG1 Reduces the IOP of Mice by Reshaping the Trabecular Outflow Pathway
Author(s): Yunsheng Qiao (1), Zhongmou Sun (2), Chen Tan (1), Junyi Lai (1), Xinghuai Sun (1,3,4), Junyi Chen (1,3,4) 1 Department of Ophthalmology...
February 28, 2023
Manhattan Vision Screening and Follow-up Study (NYC-SIGHT): Baseline Results and Costs of a Cluster-Randomized Trial
Author(s): Lisa A Hark (1), Jason D Horowitz (2), Prakash Gorroochurn (3), Lisa Park (2), Qing Wang (2), Daniel F Diamond (2), Noga Harizman (2),...
February 28, 2023