Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure

Author(s): Cheng Yang (1), Qianni Wu (2), Junqing Liu (3), Jingshan Mo (1), Xiangling Li (1,4), Chengduan Yang (1,5), Ziqi Liu (1), Jingbo Yang (1,4), Lelun Jiang (4), Weirong Chen (2), Hui-Jiuan Chen (1), Ji Wang (5), Xi Xie (6,7)

1 State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou, 510006, China.
2 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510006, China.
3 Department of Cardiology, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
4 School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou, 510006, China.
5 The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou, 510006, China.
6 State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou, 510006, China. xiexi27@mail.sysu.edu.cn.
7 The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou, 510006, China. xiexi27@mail.sysu.edu.cn.

Engineering wearable devices that can wirelessly track intraocular pressure and offer feedback-medicine administrations are highly desirable for glaucoma treatments, yet remain challenging due to issues of limited sizes, wireless operations, and wireless cross-coupling. Here, we present an integrated wireless theranostic contact lens for in situ electrical sensing of intraocular pressure and on-demand anti-glaucoma drug delivery. The wireless theranostic contact lens utilizes a highly compact structural design, which enables high-degreed integration and frequency separation on the curved and limited surface of contact lens. The wireless intraocular pressure sensing modulus could ultra-sensitively detect intraocular pressure fluctuations, due to the unique cantilever configuration design of capacitive sensing circuit. The drug delivery modulus employs an efficient wireless power transfer circuit, to trigger delivery of anti-glaucoma drug into aqueous chamber via iontophoresis. The minimally invasive, smart, wireless and theranostic features endow the wireless theranostic contact lens as a highly promising system for glaucoma treatments.

© 2022. The Author(s).

Nat Commun. 2022 May 17;13(1):2556. doi: 10.1038/s41467-022-29860-x.

PMID: 35581184 PMCID: PMC9114010 DOI: 10.1038/s41467-022-29860-x

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