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  • Tip: Not every peripapillary hemorrhage is a sign for glaucoma

    The Science behind the Tip Most of the time, disc hemorrhages in patients with glaucoma are related to the disease itself. Although the strong...

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    Tip: Not every peripapillary hemorrhage is a sign for glaucoma

    Tip: Not every peripapillary hemorrhage is a sign for glaucoma

    The Science behind the Tip Most of the time, disc hemorrhages in patients with glaucoma are...

    Learn more...
  • The Factors Affecting the Stability of IOP Homeostasis

    Purpose: Shear-induced nitric oxide (NO) production by Schlemm's canal (SC) endothelial cells provides a fast, IOP-sensitive feedback signal that...

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    The Factors Affecting the Stability of IOP Homeostasis

    The Factors Affecting the Stability of IOP Homeostasis

    Purpose: Shear-induced nitric oxide (NO) production by Schlemm's canal (SC) endothelial cells...

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  • Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study

    Purpose: To evaluate the performance of an intensive, clustered testing approach in identifying eyes with rapid glaucoma progression over 6 months...

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    Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study

    Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study

    Purpose: To evaluate the performance of an intensive, clustered testing approach in identifying...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

    Learn more...
    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

    Learn more...
  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

    Learn more...
    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

    Learn more...
  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Tip: Not every peripapillary hemorrhage is a sign for glaucoma

Tip of the month

Tip: Not every peripapillary hemorrhage is a sign for glaucoma

The Science behind the Tip Most of the time, disc hemorrhages in patients with glaucoma are related to the disease itself. Although the strong...

June 16, 2024

Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

Tip of the month

Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma

The Science behind the Tip The objective of clinical intervention in patients with glaucoma is to slow down disease progression. Intraocular...

May 15, 2024

Systemic β-blockers may have a heterogenous impact on glaucoma patients

Tip of the month

Systemic β-blockers may have a heterogenous impact on glaucoma patients

The Science behind the Tip Systemic β-blockers could reach the ciliary body epithelium and are associated with lower intraocular pressure. Thus,...

April 15, 2024

Beware of acute corneal oedema after SLT in selected patients

Tip of the month

Beware of acute corneal oedema after SLT in selected patients

The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT) has brought attention to rare side effects such as...

March 14, 2024

Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

Tip of the month

Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure

The Science behind the Tip Gonioscopy remains the gold standard for confirming iridotrabecular contact and diagnosing angle closure.1 AS-OCT and...

February 12, 2024

Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

Tip of the month

Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression

The Science behind the Tip The identification of an individual´s genetic risk of a disease is increasingly recognized as a tool in disease risk...

January 15, 2024

Selective Laser Trabeculoplasty can be considered lifesaving treatment for the cornea when severe ocular disease co-exists with glaucoma

Tip of the month

Selective Laser Trabeculoplasty can be considered lifesaving treatment for the cornea when severe ocular disease co-exists with glaucoma

The Science behind the Tip Elevated intraocular pressure (IOP) and glaucoma are not uncommon in cases of cicatricial conjunctivitis (CC) such as...

December 17, 2023

Exfoliation (pseudoexfoliation) syndrome (XFS, with or without glaucoma) is associated with clinically significant non-vascular systemic diseases.

Tip of the month

Exfoliation (pseudoexfoliation) syndrome (XFS, with or without glaucoma) is associated with clinically significant non-vascular systemic diseases.

The Science behind the Tip Systemic vascular dysfunction in XFS patients and statistically significant associations of systemic diseases with XFS...

November 15, 2023

Consider sources of bias when using OCT angiography

Tip of the month

Consider sources of bias when using OCT angiography

The Science behind the Tip OCT angiography (OCTA) has gained great interest in glaucoma diagnosis (1, 2) and follow up(3). However, several...

October 15, 2023

OCT Imaging of glaucoma patients at 6-month intervals may enhance progression detection while reducing the healthcare burden of more frequent testing

Tip of the month

OCT Imaging of glaucoma patients at 6-month intervals may enhance progression detection while reducing the healthcare burden of more frequent testing

The Science behind the Tip Thanks to its high reproducibility,1-3 OCT has become widely used for monitoring structural optic nerve changes in...

September 15, 2023

Glaucoma control can be detrimentally affected by recurrent anti- VEGF treatment for macular degeneration or diabetic macular oedema

Tip of the month

Glaucoma control can be detrimentally affected by recurrent anti- VEGF treatment for macular degeneration or diabetic macular oedema

The Science behind the Tip Patients undergoing anti-VEGF (vascular endothelial growth factor) therapy for age-related macular degeneration or...

August 31, 2023

Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

Tip of the month

Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

July 30, 2023

When interpreting RNFL OCT scans, attention should be paid to the presence of peripapillary retinoschisis

Tip of the month

When interpreting RNFL OCT scans, attention should be paid to the presence of peripapillary retinoschisis

Peripapillary retinoschisis (PPRS) occurs significantly more frequently in glaucoma patients (1%-6%) compared to healthy subjects (0.5%) (1). The...

June 30, 2023

OCT can be a helpful additional tool to differentiate glaucoma from other optic neuropathi

Tip of the month

OCT can be a helpful additional tool to differentiate glaucoma from other optic neuropathi

Differentiating between glaucomatous and non-glaucomatous optic neuropathies can be quite challenging. In addition to a thorough clinical history...

May 31, 2023

Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

Tip of the month

Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

April 21, 2023

Use corneal hysteresis to identify high-risk glaucoma patients

Tip of the month

Use corneal hysteresis to identify high-risk glaucoma patients

Identifying those patients at greater risk of disease progression is a key step in glaucoma management algorithms. Several variables have been...

March 31, 2023

Transconjunctival suturing techniques to treat over-filtration following trabeculectomy

Tip of the month

Transconjunctival suturing techniques to treat over-filtration following trabeculectomy

Hypotony is a recognised complication following filtration surgery such as trabeculectomy (1). Where this is due to over-filtration, intervention...

February 28, 2023

Be aware of obstructive sleep apnoea as a risk factor for the development or progression of glaucoma

Tip of the month

Be aware of obstructive sleep apnoea as a risk factor for the development or progression of glaucoma

Obstructive sleep apnoea (OSA) affects almost 1 billion people aged 30-69 years worldwide, of which 425 million have a moderate to severe OSA (1)....

January 31, 2023

Consider glaucoma drainage implant in patients with iridocorneal endothelial syndrome

Tip of the month

Consider glaucoma drainage implant in patients with iridocorneal endothelial syndrome

Glaucoma occurs in up to 70% of patients with iridocorneal endothelial syndrome (ICE) (1). Given the high failure rate of medical treatment,...

December 30, 2022

Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients

Tip of the month

Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients

Publishing date: November 2022 Primary congenital glaucoma leads to blindness if not treated adequate. Typical symptoms are epiphora, photophobia...

December 19, 2022

Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients

Tip of the month

Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients

Primary congenital glaucoma leads to blindness if not treated adequate. Typical symptoms are epiphora, photophobia and blepharospasm. The elevated...

November 30, 2022

Consider evaluation of corneal endothelial cell count in pseudoexfoliation patients undergoing surgery

Tip of the month

Consider evaluation of corneal endothelial cell count in pseudoexfoliation patients undergoing surgery

Corneal endothelial cell loss may lead to corneal decompensation with loss of vision, which may necessitate future endothelial transplantation for...

October 31, 2022

When glaucoma is not glaucoma

Tip of the month

When glaucoma is not glaucoma

An increased excavation of the optic nerve head is usually associated to glaucoma, but other optic neuropathies may also display an increased...

September 30, 2022

Be aware of IOP elevation in children treated with systemic glucocorticoids

Tip of the month

Be aware of IOP elevation in children treated with systemic glucocorticoids

Children have a high risk of developing IOP elevation with topical steroid-treatment, but may also develop it after systemic treatment (1–3). The...

July 30, 2022

UGH syndrome should be considered in every pseudophakic patient, with active unilateral inflammation and elevated intraocular pressure

Tip of the month

UGH syndrome should be considered in every pseudophakic patient, with active unilateral inflammation and elevated intraocular pressure

Uveitis-Glaucoma-Hyphaema (UGH) Syndrome is a rare syndrome characterized by iris transillumination defects, microhyphaemas and pigmentary...

June 30, 2022