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  • Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization

    Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the pathogenesis of primary open-angle glaucoma (POAG), the...

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    Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization

    Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization

    Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the...

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  • Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study

    Key Points Question: Do participants in the Ocular Hypertension Treatment Study with preperimetric primary open-angle glaucoma (POAG) have lower...

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    Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study

    Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study

    Key Points Question: Do participants in the Ocular Hypertension Treatment Study with...

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  • Fatal beauty: which cosmetics are your glaucoma patients using?

    Colorism refers to the difference in social treatment between light-skinned and dark-skinned people. This sociological concept is a result of...

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    Fatal beauty: which cosmetics are your glaucoma patients using?

    Fatal beauty: which cosmetics are your glaucoma patients using?

    Colorism refers to the difference in social treatment between light-skinned and dark-skinned...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

Pearl

Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

September 01, 2021

Early Lens Extraction for Primary Angle Closure Glaucoma – Implications of the EAGLE Trial

Pearl

Early Lens Extraction for Primary Angle Closure Glaucoma – Implications of the EAGLE Trial

Pearls Manager: Hari Jayaram Patients newly diagnosed with Primary Angle Closure Glaucoma without advanced damage or Primary Angle Closure with IOP...

July 30, 2021

Drops or SLT as First Line Treatment? – Implications of the LiGHT Trial

Pearl

Drops or SLT as First Line Treatment? – Implications of the LiGHT Trial

Pearls Manager: Hari Jayaram Newly diagnosed patients with Ocular Hypertension or Open Angle Glaucoma were randomised to one of two treatment...

June 30, 2021

Observation or Laser Peripheral Iridotomy? – Implications of the ZAP Trial

Pearl

Observation or Laser Peripheral Iridotomy? – Implications of the ZAP Trial

Pearls Manager: Hari Jayaram The ZAP study was a single-centre randomised clinical trial performed in China to compare Laser Peripheral Iridotomy...

May 30, 2021

Observation or Treatment? – Implications of the Ocular Hypertension Treatment Study

Pearl

Observation or Treatment? – Implications of the Ocular Hypertension Treatment Study

Pearls Manager: Hari Jayaram The OHTS was a multicentre randomised clinical trial designed to study the effect of topical ocular hypotensive...

April 30, 2021

Patient Co-operation is Essential to Achieve IOP-Lowering and Successful Outcomes

Pearl

Patient Co-operation is Essential to Achieve IOP-Lowering and Successful Outcomes

Pearls Manager: Hari Jayaram Adherence and continued usage of (“persistence”) prescribed glaucoma management is necessary to achieve sustained IOP...

March 30, 2021

Glaucoma associated with retinal detachment

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Glaucoma associated with retinal detachment

Pearls Manager: Andrew Tatham Retinal detachment is usually associated with reduction of intraocular pressure (IOP) but long standing retinal...

March 20, 2021

Visual Field Progression

Pearl

Visual Field Progression

Pearls Manager: Andrew Tatham Visual field progression analyses may be event or trend-based. Trend analyses quantify rate of progression, usually...

February 21, 2021

Anxiety associated with glaucoma

Pearl

Anxiety associated with glaucoma

Pearls Manager: Andrew Tatham Diagnosis with glaucoma is a moment of anxiety for patients that can be mitigated by provision of timely support and...

February 20, 2021

Anterior chamber angle imaging cannot replace gonioscopy

Pearl

Anterior chamber angle imaging cannot replace gonioscopy

Pearls Manager: Andrew Tatham Anterior chamber angle imaging devices can be useful to identify the iris configuration of a narrow angle, to assess...

January 30, 2021

Glaucoma associated with retinal detachment

Pearl

Glaucoma associated with retinal detachment

Pearls Manager: Andrew Tatham Retinal detachment is usually associated with reduction of intraocular pressure (IOP) but long standing retinal...

January 30, 2021

Optical coherence tomography for glaucoma diagnosis

Pearl

Optical coherence tomography for glaucoma diagnosis

Pearls Manager: Andrew Tatham Optical coherence tomography (OCT) on its own does not provide a clinical diagnosis of glaucoma, just a statistical...

December 30, 2020

Minimally invasive and micro incisional glaucoma surgery

Pearl

Minimally invasive and micro incisional glaucoma surgery

Pearls Manager: Andrew Tatham Surgical procedures that entail less tissue manipulation with the expectation of a better safety profile and quicker...

November 30, 2020

Malignant glaucoma

Pearl

Malignant glaucoma

Pearls Manager: Andrew Tatham Malignant glaucoma or aqueous misdirection is a rare type of secondary angle closure glaucoma most commonly...

October 20, 2020

Optimising eye drop instillation

Pearl

Optimising eye drop instillation

Pearls Manager: Andrew Tatham When two eye drops are instilled 30 seconds apart, almost 50% of the first drug will be washed out. It is recommended...

September 30, 2020

The Collaborative Normal Tension Glaucoma Study (CNTGS)

Pearl

The Collaborative Normal Tension Glaucoma Study (CNTGS)

Pearls Manager: Andrew Tatham The CNTGS compared treatment versus no treatment in patients with normal tension glaucoma who had verified...

July 30, 2020

Wound healing is one of the main determinants of long-term intraocular pressure control after filtering surgery

Pearl

Wound healing is one of the main determinants of long-term intraocular pressure control after filtering surgery

Pearls Manager: Andrew Tatham Risk factors for conjunctival scarring include young age, African ancestry, inflammatory eye disease, long-term...

June 18, 2020

Individualized glaucoma treatment

Pearl

Individualized glaucoma treatment

Pearls Manager: Andrew Tatham Individualized glaucoma treatment aims at providing glaucoma management tailored to the individual needs of the...

May 30, 2020

Glaucoma associated with retinal detachment

Pearl

Glaucoma associated with retinal detachment

Pearls Manager: Andrew Tatham Retinal detachment is usually associated with reduction of intraocular pressure (IOP) but long standing retinal...

March 30, 2020

Visual Field Progression

Pearl

Visual Field Progression

Pearls Manager: Andrew Tatham Visual field progression analyses may be event or trend-based. Trend analyses quantify rate of progression, usually...

February 20, 2020

The Ocular Hypertension Treatment Study (OHTS)

Pearl

The Ocular Hypertension Treatment Study (OHTS)

Pearls Manager: Andrew Tatham The OHTS was a multicentre randomised clinical trial designed to study the effect of topical ocular hypotensive...

December 20, 2019

How should we define target intraocular pressure?

Pearl

How should we define target intraocular pressure?

Pearls Manager: Andrew Tatham Target IOP is the upper limit of IOP estimated to be compatible with a rate of progression sufficiently slow to...

December 02, 2019

Glaucoma following childhood cataract surgery

Pearl

Glaucoma following childhood cataract surgery

Pearls Manager: Andrew Tatham Secondary glaucoma is a frequent serious complication after cataract surgery in early infancy. The incidence may...

November 30, 2019

Gonioscopy is essential for evaluating patients with a suspected or confirmed diagnosis of glaucoma

Pearl

Gonioscopy is essential for evaluating patients with a suspected or confirmed diagnosis of glaucoma

Pearls Manager: Andrew Tatham The corneal wedge method is helpful for identifying Schwalbe’s line, a collagen condensation of the Descemet’s...

October 22, 2019

Clinical examination of the optic nerve head

Pearl

Clinical examination of the optic nerve head

Pearls Manager: Andrew Tatham Cup/disc ratio (CDR) depends on optic disc size. A large CDR in an eye with a normal large disc may be erroneously...

September 30, 2019