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  • Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization

    Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the pathogenesis of primary open-angle glaucoma (POAG), the...

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    Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization

    Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization

    Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the...

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  • Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study

    Key Points Question: Do participants in the Ocular Hypertension Treatment Study with preperimetric primary open-angle glaucoma (POAG) have lower...

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    Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study

    Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study

    Key Points Question: Do participants in the Ocular Hypertension Treatment Study with...

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  • Fatal beauty: which cosmetics are your glaucoma patients using?

    Colorism refers to the difference in social treatment between light-skinned and dark-skinned people. This sociological concept is a result of...

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    Fatal beauty: which cosmetics are your glaucoma patients using?

    Fatal beauty: which cosmetics are your glaucoma patients using?

    Colorism refers to the difference in social treatment between light-skinned and dark-skinned...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Indefinite use of cycloplegics can be the last resort when surgery for malignant glaucoma has failed

Tip of the month

Indefinite use of cycloplegics can be the last resort when surgery for malignant glaucoma has failed

The Science behind the Tip Malignant glaucoma or aqueous misdirection is a rare but feared complication of anterior segment surgery. It occurs in...

March 31, 2013

Young men of European ancestry with angle-closure require thorough investigation

Tip of the month

Young men of European ancestry with angle-closure require thorough investigation

The Science behind the Tip Primary angle closure glaucoma is rare in younger white adults, with an estimated age specific prevalence of 0.02% for...

February 28, 2013

Intravitreal steroids should be used with caution in patients with glaucoma

Tip of the month

Intravitreal steroids should be used with caution in patients with glaucoma

The Science behind the Tip In recent years it has become common practice to inject steroids into the vitreous to reduce macular oedema or ocular...

December 31, 2012

Long-term application of benzalkonium chloride increases the risk of filtration surgery failure

Tip of the month

Long-term application of benzalkonium chloride increases the risk of filtration surgery failure

The Science behind the Tip Glaucoma medication solutions usually contain the preservative benzalkonium chloride (BAK) in concentrations varying...

November 30, 2012

In patients with pseudoexfoliation glaucoma, phacoemulsification with IOL implantation can result in a late, sustained reduction in intraocular pressure

Tip of the month

In patients with pseudoexfoliation glaucoma, phacoemulsification with IOL implantation can result in a late, sustained reduction in intraocular pressure

The Science behind the Tip Raised intraocular pressure (IOP) in an eye with pseudoexfoliation syndrome results from pigment and exfoliation...

October 31, 2012

Topical carbonic anhydrase inhibitors can cause damage in corneas with severe endothelial dysfunction

Tip of the month

Topical carbonic anhydrase inhibitors can cause damage in corneas with severe endothelial dysfunction

The Science behind the Tip The enzyme carbonic anhydrase is present in the corneal endothelium where it is involved in fluid transport (1). It thus...

September 30, 2012

In patients with progressive normal tension glaucoma, the use of topical brimonidine may help to preserve visual function

Tip of the month

In patients with progressive normal tension glaucoma, the use of topical brimonidine may help to preserve visual function

The Science behind the Tip A recent study has shown that visual function is more likely to be preserved with brimonidine 2% than with timolol 0.5%...

June 30, 2012

A dry eye can hamper visual field test interpretation

Tip of the month

A dry eye can hamper visual field test interpretation

The Science behind the Tip During visual field (VF) testing the cornea of patients with severe dry eye condition can get dry to such an extent as...

May 31, 2012

Laser peripheral iridotomy can reduce the intraocular pressure in pigment dispersion syndrome, but may not prevent glaucoma

Tip of the month

Laser peripheral iridotomy can reduce the intraocular pressure in pigment dispersion syndrome, but may not prevent glaucoma

The Science behind the Tip Nd-YAG laser peripheral iridotomy (PI) eliminates the reverse pressure gradient and intermittent posterior bowing of the...

April 30, 2012

Gonioscopy should be performed using the minimal possible levels of illumination in order to reliably detect appositional angle closure

Tip of the month

Gonioscopy should be performed using the minimal possible levels of illumination in order to reliably detect appositional angle closure

The Science behind the Tip Anterior chamber angle width varies dramatically with illumination (figure and video in ref. 1) (1,2). Visible...

March 31, 2012

Laser peripheral iridotomy does not usually result in long-term intraocular pressure control in patients with chronic angle-closure glaucoma

Tip of the month

Laser peripheral iridotomy does not usually result in long-term intraocular pressure control in patients with chronic angle-closure glaucoma

The Science behind the Tip The initial treatment of chronic angle-closure glaucoma is to undertake a laser peripheral iridotomy (PI) to prevent...

February 29, 2012

Trial lens artifacts can be easily distinguished from glaucomatous field defects

Tip of the month

Trial lens artifacts can be easily distinguished from glaucomatous field defects

The Science behind the Tip False depressions due to a misaligned trial lens or a lens holder which was placed too far from the patient's eye are...

January 31, 2012

In neovascular glaucoma, the immediate injection of intravitreal bevacizumab (Avastin®) usually results in rapid regression of iris new vessels and pain relief

Tip of the month

In neovascular glaucoma, the immediate injection of intravitreal bevacizumab (Avastin®) usually results in rapid regression of iris new vessels and pain relief

The Science behind the Tip Neovascular glaucoma is a devastating consequence of diseases like proliferative diabetic retinopathy and ischaemic...

December 31, 2011

Washout periods vary significantly between glaucoma medications

Tip of the month

Washout periods vary significantly between glaucoma medications

The Science behind the Tip Knowledge of the washout periods for topical medications is crucial for the evaluation of the effects of their...

November 30, 2011

To prevent early hypotony with a non-valved aqeous shunt, always occlude the tube with a suture

Tip of the month

To prevent early hypotony with a non-valved aqeous shunt, always occlude the tube with a suture

The Science behind the Tip The safe use of non-valved aqueous shunt implants, such as the Baerveldt (Advanced Medical Optics, Inc., Irvine,...

October 31, 2011

Prostaglandin analogues should be avoided in patients with a history of herpes keratitis

Tip of the month

Prostaglandin analogues should be avoided in patients with a history of herpes keratitis

The Science behind the Tip Topical prostaglandins are commonly used as first-line and second-line therapy in patients with ocular hypertension and...

September 30, 2011

Rim/disc ratio is a more sensitive parameter than cup/disc ratio

Tip of the month

Rim/disc ratio is a more sensitive parameter than cup/disc ratio

The Science behind the Tip Routine fundus observation of the optic disc is helpful in the diagnosis of early glaucoma and it is often key in the...

June 30, 2011

In patients with juvenile-onset chronic open-angle glaucoma, trabeculectomy with mitomycin C is usually required to prevent progressive visual loss

Tip of the month

In patients with juvenile-onset chronic open-angle glaucoma, trabeculectomy with mitomycin C is usually required to prevent progressive visual loss

The Science behind the Tip Juvenile-onset chronic open-angle glaucoma is inherited in an autosomal dominant fashion with high penetrance....

May 31, 2011

The advantage of adding a 3rd or 4th drug may be negligible

Tip of the month

The advantage of adding a 3rd or 4th drug may be negligible

The Science behind the Tip With the arrival of combination products, our threshold for prescribing multiple glaucoma medications has significantly...

April 30, 2011

The most effective treatment of glaucoma associated with epithelial downgrowth is to insert a drainage implant

Tip of the month

The most effective treatment of glaucoma associated with epithelial downgrowth is to insert a drainage implant

The Science behind the Tip Epithelial downgrowth into the anterior chamber is an extremely rare cause of glaucoma after anterior segment incisional...

March 31, 2011

Chronic miotics can be helpful in case of plateau iris configuration

Tip of the month

Chronic miotics can be helpful in case of plateau iris configuration

The Science behind the Tip Long term miotics are seldom prescribed nowadays. Still the drugs remain useful in case of plateau iris configuration, a...

February 28, 2011

To reduce the risk of late bleb-related infection, avoid multiple-dose eye drops in patients who have previously undergone trabeculectomy with mitomycin C

Tip of the month

To reduce the risk of late bleb-related infection, avoid multiple-dose eye drops in patients who have previously undergone trabeculectomy with mitomycin C

The Science behind the Tip Bleb-related infection is a devastating and potentially blinding late consequence of trabeculectomy, particularly if...

January 31, 2011

Small field depressions can be more worrying than large ones

Tip of the month

Small field depressions can be more worrying than large ones

The Science behind the Tip Much of the decision making in modern glaucoma practice is based on automated visual field test results. Careful...

December 31, 2010

The cataract surgeon should be informed that the patient has pseudo-exfoliation syndrome

Tip of the month

The cataract surgeon should be informed that the patient has pseudo-exfoliation syndrome

The Science behind the Tip Although the diagnosis of pseudo-exfoliation syndrome (PEX) with a fully dilated pupil in an elderly patient should pose...

October 31, 2010

If conservative measures are unsuccessful in the management of malignant glaucoma, phaco with IOL combined with posterior capsulotomy and anterior vitrectomy usually is

Tip of the month

If conservative measures are unsuccessful in the management of malignant glaucoma, phaco with IOL combined with posterior capsulotomy and anterior vitrectomy usually is

The Science behind the Tip Malignant glaucoma in a phakic eye typically follows incisional surgery for primary angle-closure glaucoma. Shallowing...

September 30, 2010