Tip of the Month
Publishing date: January 2016
Tip Editors: John Salmon and Gordana Sunaric Mégevand
Tip reviewer: Roger Hitchings
The science behind the tip
Raised IOP and secondary glaucoma are common late consequences of nanophthalmos (axial length less than 20mm). Trabeculectomy should be avoided in nanophthalmos as it is associated with a high complication rate, including late choroidal effusion in 50% of patients (1). This complication occurs in approximately 5% of patients with nanophthalmos who undergo phacoemulsification with IOL implantation (2). It is thought that an abnormality of transcleral protein transport plays a primary pathogenetic role in this disorder (3).
The choroidal effusion is unlikely to settle without intervention. An effective therapeutic option is to undertake a partial thickness lamellar sclerectomy in two to three quadrants (3,4). Successful resolution occurs within 6 months in 83% of patients after one intervention and in a further 13% after a second procedure (3).
Contributor: J F Salmon MD Consultant Ophthalmologist - Oxford Eye Hospital (UK)
1. Yalvac IS, Satana B, Ozkan G. et al Management of glaucoma in patients with nanophthalmos. Eye 2008; 22: 838-43
2. Day AC, MacLaren RE, Bunce C, et al Outcomes of phacoemulsification with intraocular lens implantation in microphthalmos and nanopthalmos. J Cat Refr Surg 2013; 39: 87-96
3. Johnson MW, Gass GD. Surgical management of the idiopathic uveal effusion syndrome. Ophthalmology 1990; 97: 778-85
4. Wax MD, Kass MA, Kolker AE. Anterior lamellar sclerectomy for nanophthalmos J Glaucoma 1992; 1: 222-27