Publishing date: June 2020
Author(s): David M.Wright (1,2), Evgenia Konstantakopoulou (3,4,5), Giovanni Montesano (6), Neil Nathwani (3), Anurag Garg (3), David Garway-Heath (3,4), David P.Crabb (6), Gus Gazzard (3,4) on behalf of the LiGHT Trial Study Group
1 Centre for Public Health, Queen’s University Belfast, Belfast, UK
2 Health Data Research UK
3 NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, London, UK
4 Institute of Ophthalmology, University College London, UK
5 Division of Optics and Optometry, University of West Attica, Greece
6 Optometry and Visual Science, School of Health Science, City, University of London, London, UK
PURPOSE: To compare visual field outcomes of ocular hypertensive and glaucoma patients treated first with medical therapy with those treated first with selective laser trabeculoplasty (SLT).
DESIGN: Secondary analysis of patients from the Laser in Glaucoma and Ocular Hypertension study, a multicenter randomized controlled trial.
PARTICIPANTS: Three hundred forty-four patients (588 eyes) treated first with medical therapy and 344 patients (590 eyes) treated first with SLT.
METHODS: Visual fields (VFs) were measured using standard automated perimetry and arranged in series (median length and duration, 9 VFs over 48 months). Hierarchical linear models were used to estimate pointwise VF progression rates, which were then averaged to produce a global progression estimate for each eye. Proportions of points and patients in each treatment group with fast (<–1 dB/year) or moderate (<–0.5 dB/year) progression were compared using log-binomial regression.
MAIN OUTCOME MEASURES: Pointwise and global progression rates of total deviation (TD) and pattern deviation (PD).
RESULTS: A greater proportion of eyes underwent moderate or fast TD progression in the medical therapy group compared with the SLT group (26.2% vs. 16.9%; risk ratio http://RR, 1.55; 95% confidence interval http://CI, 1.23–1.93; P < 0.001). A similar pattern was observed for pointwise rates (medical therapy, 26.1% vs. SLT, 19.0%; RR, 1.37; 95% CI, 1.33–1.42; P < 0.001). A greater proportion of pointwise PD rates were categorized as moderate or fast in the medical therapy group (medical therapy, 11.5% vs. SLT, 8.3%; RR, 1.39; 95% CI, 1.32–1.46; P < 0.001). No statistical difference was found in the proportion of eyes that underwent moderate or fast PD progression (medical therapy, 9.9% vs. SLT, 7.1%; RR, 1.39; 95% CI, 0.95, 2.03; P = 0.0928).
CONCLUSIONS: A slightly larger proportion of ocular hypertensive and glaucoma patients treated first with medical therapy underwent rapid VF progression compared with those treated first with SLT.
Clinical Paper of the Month manager: Marta Pazos