This website uses cookies to help us give you the best browsing experience. By continuing to use this portal, you agree to our use of this tool.
To learn more about how we use cookies and how to manage them please read our notice here.
Journal Club
Clinical Paper of the Month - Mitochondrial dysfunction in ocular disease: Focus on glaucoma
Mitochondrial dysfunction in ocular disease: Focus on glaucoma

Publishing date: June 2017

Author(s): Kamel K (1), Farrell M (2), O'Brien C (3)

1 Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland.
2 Neuropathology, Beaumont Hospital, Dublin, Ireland.
3 Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. Electronic address: cobrien@mater.ie.

Mitochondrial dysfunction commonly presents with ocular findings as a part of a systemic disorder. These ophthalmic manifestations can be the first sign of a mitochondrial abnormality, which highlights the key role of a comprehensive ophthalmic assessment. On the other hand, a number of visually disabling genetic and acquired eye diseases with no curative treatment show abnormal mitochondrial function.

Recent advances in mitochondrial research have improved our understanding of previously unexplained ocular disorders utilising better diagnostic approaches. Further studies on mitochondrial dysfunction and novel modalities of treatment will help to improve outcomes of these conditions. In this review article we discuss the clinical picture of common mitochondrial-related eye diseases, diagnostic approaches and possible treatment options including a very recent interesting report about gene therapy, with a particular focus on glaucoma.

Copyright © 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

PMID: 28499981

http://www.ncbi.nlm.nih.gov/pubmed/28499981


Keywords: Glaucoma; Mitochondria; Oxidative stress; mtDNA



Clinical Paper of the Month manager: Andreas Boehm




back to top

X