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Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells
Previous studies of neuronal survival have primarily focused on identifying intrinsic mechanisms...
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Comparison of intraocular pressure profiles during the water drinking test and the modified diurnal tension curve
Objectives: To compare intraocular pressure (IOP) during the water drinking test (WDT) and...
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Systemic β-blockers may have a heterogenous impact on glaucoma patients
The Science behind the Tip Systemic β-blockers could reach the ciliary body epithelium and are...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Systemic β-blockers may have a heterogenous impact on glaucoma patients
The Science behind the Tip Systemic β-blockers could reach the ciliary body epithelium and are associated with lower intraocular pressure. Thus,...
April 15, 2024
Beware of acute corneal oedema after SLT in selected patients
The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT) has brought attention to rare side effects such as...
March 14, 2024
Various factors can result in discordance between gonioscopy and Anterior Segment Optical Coherence Tomography (AS-OCT) when assessing angle closure
The Science behind the Tip Gonioscopy remains the gold standard for confirming iridotrabecular contact and diagnosing angle closure.1 AS-OCT and...
February 12, 2024
Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression
The Science behind the Tip The identification of an individual´s genetic risk of a disease is increasingly recognized as a tool in disease risk...
January 15, 2024
Selective Laser Trabeculoplasty can be considered lifesaving treatment for the cornea when severe ocular disease co-exists with glaucoma
The Science behind the Tip Elevated intraocular pressure (IOP) and glaucoma are not uncommon in cases of cicatricial conjunctivitis (CC) such as...
December 17, 2023
Exfoliation (pseudoexfoliation) syndrome (XFS, with or without glaucoma) is associated with clinically significant non-vascular systemic diseases.
The Science behind the Tip Systemic vascular dysfunction in XFS patients and statistically significant associations of systemic diseases with XFS...
November 15, 2023
Consider sources of bias when using OCT angiography
The Science behind the Tip OCT angiography (OCTA) has gained great interest in glaucoma diagnosis (1, 2) and follow up(3). However, several...
October 15, 2023
OCT Imaging of glaucoma patients at 6-month intervals may enhance progression detection while reducing the healthcare burden of more frequent testing
The Science behind the Tip Thanks to its high reproducibility,1-3 OCT has become widely used for monitoring structural optic nerve changes in...
September 15, 2023
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Glaucoma control can be detrimentally affected by recurrent anti- VEGF treatment for macular degeneration or diabetic macular oedema
The Science behind the Tip Patients undergoing anti-VEGF (vascular endothelial growth factor) therapy for age-related macular degeneration or...
August 31, 2023
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...
July 30, 2023
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When interpreting RNFL OCT scans, attention should be paid to the presence of peripapillary retinoschisis
Peripapillary retinoschisis (PPRS) occurs significantly more frequently in glaucoma patients (1%-6%) compared to healthy subjects (0.5%) (1). The...
June 30, 2023
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OCT can be a helpful additional tool to differentiate glaucoma from other optic neuropathi
Differentiating between glaucomatous and non-glaucomatous optic neuropathies can be quite challenging. In addition to a thorough clinical history...
May 31, 2023
Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...
April 21, 2023
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Use corneal hysteresis to identify high-risk glaucoma patients
Identifying those patients at greater risk of disease progression is a key step in glaucoma management algorithms. Several variables have been...
March 31, 2023
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Transconjunctival suturing techniques to treat over-filtration following trabeculectomy
Hypotony is a recognised complication following filtration surgery such as trabeculectomy (1). Where this is due to over-filtration, intervention...
February 28, 2023
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Be aware of obstructive sleep apnoea as a risk factor for the development or progression of glaucoma
Obstructive sleep apnoea (OSA) affects almost 1 billion people aged 30-69 years worldwide, of which 425 million have a moderate to severe OSA (1)....
January 31, 2023
Consider glaucoma drainage implant in patients with iridocorneal endothelial syndrome
Glaucoma occurs in up to 70% of patients with iridocorneal endothelial syndrome (ICE) (1). Given the high failure rate of medical treatment,...
December 30, 2022
Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients
Publishing date: November 2022 Primary congenital glaucoma leads to blindness if not treated adequate. Typical symptoms are epiphora, photophobia...
December 19, 2022
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Consider axial length as an important parameter for your surgical decision in childhood glaucoma patients
Primary congenital glaucoma leads to blindness if not treated adequate. Typical symptoms are epiphora, photophobia and blepharospasm. The elevated...
November 30, 2022
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Consider evaluation of corneal endothelial cell count in pseudoexfoliation patients undergoing surgery
Corneal endothelial cell loss may lead to corneal decompensation with loss of vision, which may necessitate future endothelial transplantation for...
October 31, 2022
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When glaucoma is not glaucoma
An increased excavation of the optic nerve head is usually associated to glaucoma, but other optic neuropathies may also display an increased...
September 30, 2022
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Be aware of IOP elevation in children treated with systemic glucocorticoids
Children have a high risk of developing IOP elevation with topical steroid-treatment, but may also develop it after systemic treatment (1–3). The...
July 30, 2022
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UGH syndrome should be considered in every pseudophakic patient, with active unilateral inflammation and elevated intraocular pressure
Uveitis-Glaucoma-Hyphaema (UGH) Syndrome is a rare syndrome characterized by iris transillumination defects, microhyphaemas and pigmentary...
June 30, 2022
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Hypotony-related complications, not numerical hypotony, should alarm the clinician
Chronic hypotony, defined as a pressure of ≤5 mmHg for >3 months, may occur after glaucoma surgery (1,2). Despite being traditionally regarded...
May 31, 2022
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When choosing a glaucoma operation, be guided by the target intra-ocular pressure (IOP)
In recent years, we have seen a vast expansion of incisional surgical techniques for glaucoma with a wide range of long-term efficacy and safety...
April 30, 2022