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TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage
Purpose: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2)...
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Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma
Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by...
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Disease progression, despite intraocular pressure, should guide escalation of treatment in glaucoma
The Science behind the Tip NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Potential role of P2X7 receptor in neurodegenerative processes in a murine model of glaucoma
Author(s): Pérez de Lara MJ (1), Avilés-Trigueros M (2), Guzmán-Aránguez A (1), Valiente-Soriano FJ (2), de la Villa P (3), Vidal-Sanz M (4),...
July 31, 2019
Impact of Posterior Sclera on Glaucoma Progression in Treated Myopic Normal-Tension Glaucoma Using Reconstructed Optical Coherence Tomographic Images
Author(s): Kim YC (1), Koo YH (2), Jung KI (3), Park CK (3) 1 Department of Ophthalmology, College of Medicine, Incheon St. Mary's Hospital, The...
June 30, 2019
Rapamycin Removes Damaged Mitochondria and Protects Human Trabecular Meshwork (TM-1) Cells from Chronic Oxidative Stress
Author(s): He JN (1,2), Zhang SD (3), Qu Y (2), Wang HL (2), Tham CC (1), Pang CP (1), Chu WK (4) 1 Department of Ophthalmology and Visual...
May 31, 2019
Border Tissue Morphology is Spatially Associated with Focal Lamina Cribrosa Defect and Deep-Layer Microvasculature Dropout in Open-Angle Glaucoma
Author(s): Han JC (1), Choi JH (1), Park DY (1), Lee EJ (1), Kee C (2) 1 Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan...
April 30, 2019
Artificial intelligence and deep learning in ophthalmology
Author(s): Ting DSW (1), Pasquale LR (2), Peng L (3), Campbell JP (4), Lee AY (5), Raman R (6), Tan GSW (7), Schmetterer L (7,8,9,10), Keane PA...
March 31, 2019
Identification of Candidate miRNA Biomarkers for Glaucoma
Author(s): Hindle AG1, Thoonen R2, Jasien JV (3), Grange RMH (1), Amin K (4), Wise J (4), Ozaki M (5), Ritch R (3), Malhotra R (2), Buys ES (1) 1...
February 28, 2019
Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma
Author(s): Mathieu E (1,2,3), Gupta N (1,2,3,4,5), Paczka-Giorgi LA (1,2), Zhou X (1,2), Ahari A (1,2), Lani R (1), Hanna J (1,2,3), Yücel YH...
January 31, 2019
Residual vision activation and the brain-eye-vascular triad: Dysregulation, plasticity and restoration in low vision and blindness - a review
Author(s): Sabel BA (1), Flammer J (2), Merabet LB (3) 1 Institute of Medical Psychology, Medical Faculty, Otto-von-Guericke University of...
December 31, 2018
Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma
Author(s): Singh LN (1), Crowston JG (2), Lopez Sanchez MIG (2), Van Bergen NJ (2), Kearns LS (2), Hewitt AW (2,3), Yazar S (4,5), Mackey DA (4),...
November 30, 2018
Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma
Author(s): Bosco A(1), Anderson SR(2), Breen KT(2), Romero CO(2), Steele MR(2), Chiodo VA(3), Boye SL(3), Hauswirth WW(3), Tomlinson S(4), Vetter...
October 31, 2018
Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma
Author(s): MacGregor S (1), Ong JS (2), An J (2), Han X (2), Zhou T (3), Siggs OM (3), Law MH (2), Souzeau E (3), Sharma S (3), Lynn DJ (4,5,6),...
September 30, 2018
Nogo-A inactivation improves visual plasticity and recovery after retinal injury
Author(s): Mdzomba JB (1), Jordi N (2), Rodriguez L (1), Joly S (1), Bretzner F (3), Pernet V (4) 1 CUO-Recherche, Centre de recherche du CHU de...
July 31, 2018
Glaucoma pathogenesis and neurotrophins: Focus on the Molecular and Genetic basis for Therapeutic prospects
Author(s): Chitranshi N (1), Dheer Y (1), Abbasi M (1), You Y (2), Graham SL (1), Gupta V (1) 1 Faculty of Medicine and Health Sciences, Macquarie...
June 30, 2018
The coma in glaucoma: Retinal ganglion cell dysfunction and recovery
Author(s): Fry LE (1), Fahy E (2), Chrysostomou V (3), Hui F (2), Tang J (2), van Wijngaarden P (2), Petrou S (4), Crowston JG (5) 1 Centre for Eye...
May 31, 2018
Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma
Author(s): Huard DJE (1), Crowley VM (2), Du Y (3), Cordova RA (4), Sun Z (4), Tomlin MO (1), Dickey CA (4), Koren J 3rd (4), Blair L (4), Fu H...
April 30, 2018
Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma
Author(s): Gharahkhani P (1), Burdon KP (2), Cooke Bailey JN (3), Hewitt AW (2), Law MH (4), Pasquale LR (5), (6), Kang JH (6), Haines JL (3),...
March 31, 2018
Anesthetic Preconditioning as Endogenous Neuroprotection in Glaucoma
Author(s): Chou TH (1), Musada GR (2), Romano GL (3), Bolton E (4), Porciatti V (5) 1 Bascom Palmer Eye Institute, University of Miami Miller...
February 28, 2018
ASK1 in neurodegeneration
Author(s): Guo X (1), Namekata K (2), Kimura A (2), Harada C (2), Harada T (2) 1 Visual Research Project, Tokyo Metropolitan Institute of Medical...
January 31, 2018
Retinal Astrocytes and GABAergic Wide-Field Amacrine Cells Express PDGFRα: Connection to Retinal Ganglion Cell Neuroprotection by PDGF-AA
Author(s): Takahama S (1), Adetunji MO (1), Zhao T (2), Chen S2, Li W (2), Tomarev SI (1) 1 Section on Retinal Ganglion Cell Biology, Laboratory of...
November 30, 2017
Peptides of the variable IgG domain as potential biomarker candidates in primary open-angle glaucoma (POAG)
Author(s): Schmelter C (1), Perumal N (1), Funke S (1), Bell K (1), Pfeiffer N (1), Grus FH (1) 1 Department of Experimental and Translational...
October 31, 2017
Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes
Author(s): Van Houcke J (1), Bollaerts I (1), Geeraerts E (1), Davis B (2), Beckers A (1), Van Hove I (1), Lemmens K (1), De Groef L (3), Moons L...
October 31, 2017
Mitochondrial dysfunction in ocular disease: Focus on glaucoma
Author(s): Kamel K (1), Farrell M (2), O'Brien C (3) 1 Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. 2...
September 30, 2017
Interleukin-6 Deficiency Attenuates Retinal Ganglion Cell Axonopathy and Glaucoma-Related Vision Loss
Author(s): 1 Neuroscience Graduate Program, Vanderbilt UniversityNashville, TN, United States. 2 Department of Ophthalmology and Visual Sciences,...
July 31, 2017
Regulation of intraocular pressure by microRNA cluster miR-143/145
Author(s): Li X (1,2), Zhao F (3,4), Xin M (5), Li G (6), Luna C (6), Li G (1), Zhou Q (4), He Y (2), Yu B (4), Olson E (7), Gonzalez P (6), Wang S...
June 30, 2017
Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma
Author(s): Zhu W (1), Jain A (2), Gramlich OW (3), Tucker BA (3), Sheffield VC (4), Kuehn MH (1) 1 Department of Ophthalmology and Visual Sciences,...
May 31, 2017