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Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells
Previous studies of neuronal survival have primarily focused on identifying intrinsic mechanisms...
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Comparison of intraocular pressure profiles during the water drinking test and the modified diurnal tension curve
Objectives: To compare intraocular pressure (IOP) during the water drinking test (WDT) and...
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Systemic β-blockers may have a heterogenous impact on glaucoma patients
The Science behind the Tip Systemic β-blockers could reach the ciliary body epithelium and are...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Be aware of glaucoma therapy-related ocular surface disease when planning filtration surgery!
Glaucoma eye drops, especially when containing preservatives, are responsible for clinical or subclinical ocular surface alterations (1). Amongst...
March 31, 2022
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When prescribing Latanoprost, don’t forget about potential cardiovascular side effects
Prostaglandin analogues are advised as first line treatment for chronic open angle glaucoma by the European Glaucoma Society Guidelines for their...
February 28, 2022
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Unilateral ocular hypertension: have a look at the corneal endothelium
Unilateral ocular hypertension or glaucoma is often associated with secondary causes that should be explored to ascertain the visual prognosis and...
January 31, 2022
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Mind the depth – forward displacement of the lens-iris diaphragm and myopic shift after ophthalmic surgery is suggestive of aqueous misdirection
Aqueous misdirection is a serious condition with potentially higher prevalence than expected. Predominantly observed after ocular surgery,...
December 31, 2021
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Exfoliation (pseudoexfoliation) syndrome (with or without glaucoma) is associated with clinically significant non-vascular systemic diseases
The association of systemic vascular dysfunction and vascular diseases with exfoliation syndrome have been extensively studied in the last decades....
December 01, 2021
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Consider trabeculectomy as initial treatment for newly diagnosed advanced primary open angle glaucoma (POAG)
IOP control is of uttermost importance in advanced glaucoma to prevent blindness. The EGS guidelines recommend IOP in the low teens, e.g. 10-12mmHg...
October 31, 2021
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Take a look at the deviation maps when assessing structural change in glaucoma
The structural analysis of the thickness of peripapillary retinal nerve fiber layer (pRNFL) and the inner layers of the posterior pole with optical...
September 30, 2021
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In patients with unilateral angle recession glaucoma, the non-traumatized fellow eye should also be periodically checked
Angle recession (AR) is a common complication after a blunt ocular trauma, and it is related to a higher risk of developing late-onset glaucoma...
July 31, 2021
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Consider Charles Bonnet syndrome in glaucoma patients even if visual acuity is still good
Charles Bonnet syndrome (CBS) describes the presence of complex visual hallucinations with retained insight in the unreal nature of the phenomenon...
June 30, 2021
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Consider focal pressure in case of poor filtration shortly after trabeculectomy
Achieving a good filtration in the early postoperative period after trabeculectomy is associated with the procedure's long-term success (1)....
May 31, 2021
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Ganglion cell-inner plexiform layer examination can help diagnose glaucoma in high myopia
Myopia can be associated with significant structural changes in the eye, including peripapillary atrophy, myopic macular degeneration and the...
April 30, 2021
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My personal way to estimate whether a patient is at risk for wipeout following glaucoma surgery, is to perform a confrontation visual field with a red-topped bottle
This should be done monocularly with the bottle moved from the area of scotoma towards fixation. One must ensure that the patient is constantly...
March 31, 2021
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Consider IOP monitoring and prophylactic treatment in patients undergoing repeat intravitreal anti-VEGF injections
Intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections are now in widespread use for a plethora of retinal diseases. It is...
February 28, 2021
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In glaucoma patients with anterior uveitis using brimonidine, one must consider `brimonidine-associated uveitis` to avoid misdiagnosis and over-treatment
Raised intraocular pressure (IOP) and secondary glaucoma due to underlying uveitis is a well-acknowledged phenomenon (1). The clinician should...
January 31, 2021
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The side effects of timolol and other beta-adrenergic antagonists on the cardiovascular and pulmonary system in predisposed patients should not be underestimated
Since 1976 beta-adrenergic antagonists have established their role in the effective lowering of the intraocular pressure. The potential side...
December 31, 2020
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Trabecular meshwork bypass surgery should be avoided if high episcleral venous pressure is suspected
The intraocular pressure lowering effect of procedures that attempt to enhance flow of aqueous into Schlemm’s canal by bypassing or cutting the...
November 30, 2020
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Haemodialysis can cause an acute rise in intraocular pressure
Haemodialysis (HD) can reportedly induce a sudden rise in intraocular pressure (IOP) in patients with neovascular (NVG) (1) and pseudo-exfoliative...
October 31, 2020
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Glaucoma progression: watch out the fellow, non-progressing eye
In clinical practice, the detection of visual field progression in one eye usually leads to management modifications in that eye. Less attention is...
September 30, 2020
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Take care not to miss glaucomatous cupping in patients with small discs!
The Science behind the Tip The diagnosis of glaucoma can be missed in patients with small optic discs (1). In such patients, relative crowding of...
July 31, 2020
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Ask your glaucoma patients about mobility rather than vision
The Science behind the Tip Self-reported visual disability in glaucoma which correlates with level of visual field loss includes bumping into...
June 30, 2020
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Glaucoma patients on topical treatment should be routinely checked for signs of ocular surface disease even if they are asymptomatic
The Science behind the Tip The prevalence of ocular surface disease is significantly higher in glaucoma patients (1). While generally accepted that...
May 31, 2020
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Late in-the-bag intraocular lens dislocation several years after uncomplicated cataract surgery is relatively common in pseudoexfoliation
The Science behind the Tip In pseudoexfoliation syndrome (PSX) and pseudoexfoliative glaucoma (PSG) progressive zonular damage frequently leads to...
March 31, 2020
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Consider Brinzolamide to prevent IOP Spikes after Cataract Surgery in Eyes with Glaucoma
The Science behind the Tip IOP spikes, i.e. an IOP elevation after surgery compared to baseline, often occur in eyes with glaucoma.2 IOP spikes may...
February 28, 2020
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When intraocular pressure lowering does not halt visual field progression in an eye which has classic features of glaucoma (glaucoma cupping, retinal nerve fiber loss and normal visual acuity and colour vision), a diagnosis of compressive optic neuropathy should be considered. While disc pallor is recognised to be a sign of potential ominous disease, it should be appreciated that in the early stages of compressive optic neuropathy, the disc may maintain its normal colour
The Science behind the Tip Axonal loss decreases the volume of the disc, and if loss is concentrated in one area without significant gliosis,...
December 31, 2019
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While adherence to therapy is undoubtedly important, at least equally important is the patient’s adherence to a prescribed follow up schedule. Therapies can fail over time and missing follow up appointments can be particularly hazardous for fast progressors-practitioners should stress the importance of good follow up
The Science behind the Tip Clinical trials have shown us average rates of progression and average ideal IOP readings for populations of patients...
November 30, 2019